Functional Annotation and Protein Families: from Theory to Practice
نویسندگان
چکیده
Section 2. Then we present ProtoNet. ProtoNet is centered around the concept of homology transitivity. ProtoNet clusters protein sequences into a hierarchy based on sequence similarity and homology transitivity. Thus the hierarchy parallels the evolutionary history of these protein sequences. We then illustrate—using Histone proteins—the application of ProtoNet to detect remote protein relatives.
منابع مشابه
Family relationships: should consensus reign? - consensus clustering for protein families
MOTIVATION Reliable identification of protein families is key to phylogenetic analysis, functional annotation and the exploration of protein function diversity in a given phylogenetic branch. As more and more complete genomes are sequenced, there is a need for powerful and reliable algorithms facilitating protein families construction. RESULTS We have formulated the problem of protein familie...
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